Laboratory Medicine Program

PAH clearance (Research Only)

Clinical Decription:
The renal plasma clearance of a substance which is completely removed from the blood by the kidneys is equal to the renal plasma flow. At low plasma concentrations the p-aminohippuric acid (PAH) clearance is between 85-100% of the renal plasma flow, and is known as the "effective renal plasma flow". most kidney diseases result in a decreased rate of effective renal plasma flow. The estimation of the PAH clearance provides a measure of the extent of kidney damage.
<br/><em>Smith IIW, J Clin Invest 1945;24:388 Bratoon AC, J Biol Chem 1939;128:537</em>

Method: Colorimetric; Colourimetric microplate

Component Tests Used: n/a

Reference Ranges Used:
600 - 700 mL/min

Specimen Type: Red, no additive and random urine
Volume: 4.0 serum, 2.0 urine mL (minimum: 1.0 serum, 1.0 urine mL)

Shipping: Send frozen on dry ice.

Special Instructions: Centrifuge and aliquot.

Testing Schedule(s): on request, but must be a minimum of 25 samples, 4 week prior arrangement.

Turnaround Time: 20 days

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For more information, call 416.340.5227 or 1.866.865.5227

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