Laboratory Medicine Program

Angiotensinogen, angiotensin 1 (Research only)
(PRA, Hypertension, Angiotonin)

Clinical Decription:
Angiotensin I is a vasopressor substance that is formed in the body by interaction of renin and a serum globulin fraction (angiotensinogen). Angiotensin I is the physiologically inactive form of angiotensin, precursor of angiotensin II. This test involves a radioimmunoassay procedure for the direct estimation of the primary product of renin activity, angiotensin I. Under the conditions of this assay, the accumulation of angiotensin I is favoured by allowing the endogenous renin and substrate to react in the presence of reagents which inhibit both plasma converting enzyme and proteolysis by angiotensinases.
<br/><em>NEN Life Science Products Angiotensin I RIA package insert. Davis FA. Taber's Cyclopedic Medical Dictionary, 14 ed. Philadelphia, 1968:84 </em>

Method: RIA; RIA

Component Tests Used: n/a

Reference Ranges Used:
N/A

Specimen Type: Citrated plasma
Collected In: EDTA
Volume: 3 mL (minimum: 1 mL)

Shipping: Sample on dry ice

Special Instructions: Pre-chill tube before collection. Keep on ice before separating. Centrifuge and aliquot sample.

Testing Schedule(s): on request, but must be a minimum of 25 samples, 4 week prior arrangement.

Turnaround Time: 20 days

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For more information, call 416.340.5227 or 1.866.865.5227

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