Laboratory Medicine Program

Fondaparinux
(Arixtra)

Clinical Decription:
Fondaparinux is a synthetic pentasaccharide. Fondaparinux is an indirect anticoagulant that exerts its anticoagulant effect by combining with antithrombin. The fondaparinux-antithrombin complex inhibits only coagulation factor Xa. Half-life is 17-21 hours, and it is renally cleared.

Method: Chromogenic; Siemens Sysmex CS-5100

Component Tests Used: n/a

Reference Ranges Used:
Fondaparinux has been used as a reference standard in this assay. The therapeutic anti-Xa range for Fondaparinux has not been established. For 2.5 mg daily dose expected range is 0.20 to 0.40 ug/mL. For 7.5 mg daily dose expected range is 0.50 to 1.50 ug/mL. ACCP 2008

Specimen Type: Citrated plasma
Collected In: 3.2% Sodium Citrate
Volume: 1.0 mL (minimum: 1.0 mL)

Shipping: Send frozen on dry ice.

Special Instructions: Patient should be fasting, if possible. The specimen must be double-centrifuged to obtain a platelet-poor plasma specimen (Plt <10x10E9/L): 1. Immediately centrifuge specimen at 1500xG for 10 minutes. 2. Separate the plasma from the platelet/buffy coat and transfer into a clean plastic tube. 3. Centrifuge the separated plasma at 1500xG for 10 minutes. 4. Transfer 1.0 to 2.0 mL of the double-centrifuged plasma into a clean plastic tube, leaving approx. 200 uL for discard. 5. Freeze plasma aliquot immediately for storage. Maintain frozen for shipping and handling.

Testing Schedule(s): Daily.

Turnaround Time: 1 day

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