Laboratory Medicine Program

Myositis Antibodies Profile

Clinical Decription:
Qualitative detection of IgG autoantibodies to 16 antigens associated with autoimmune inflammatory myopathies: Mi-2a, Mi-2ß, TIF1?, MDA5, NXP2, SAE1, Ku, PM-Scl100, PM-Scl75, Jo-1, SRP, PL-7, PL-12, EJ, OJ and Ro-52. The identification of these autoantibodies can support the diagnosis of dermato- and polymyositis, idiopathic myositis, antisynthetase syndrome, inclusion body myositis, and overlapping syndromes. Simultaneous investigation of myositis-specific antibodies in a large profile can significantly increase the serological detection rate. The isolated presence of autoantibodies against individual myositis-specific antigens is characteristic for autoimmune myositides.

Method: Immunoblot; EUROBlot Master

Component Tests Used: Qualitative detection of IgG autoantibodies to 16 antigens associated with autoimmune inflammatory myopathies: Mi-2a, Mi-2ß, TIF1?, MDA5, NXP2, SAE1, Ku, PM-Scl100, PM-Scl75, Jo-1, SRP, PL-7, PL-12, EJ, OJ and Ro-52.

Reference Ranges Used:
Negative

Specimen Type: serum or plasma
Volume: 3 mL (minimum: 1 mL)

Shipping: frozen serum

Special Instructions: centrifuge and aliquot. ship frozen

Testing Schedule(s): Please call

Turnaround Time: 10 Business days

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For more information, call 416.340.5227 or 1.866.865.5227

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