Laboratory Medicine Program

AXIN2-related Attenuated Familial Adenomatous Polyposis (AXIN2)

Clinical Decription:
The AXIN2 gene is associated with an oligodontia-cancer predisposition syndrome. This is a rare, genetic, odontologic disease characterized by congenital absence of six or more permanent teeth (excluding the third molars) in association with an increased risk for malignancies, ranging from gastrointestinal polyposis to early-onset colorectal cancer and/or breast cancer. Ectodermal dysplasia (manifesting with sparse hair and/or eyebrows) may also be associated. Note: This is a blood test for individuals with clinical features and/or a family history of AXIN2-related attenuated familial adenomatous polyposis. It is not a tumour test for somatic gene variants that provide information about diagnostics, prognostics or therapeutics.

Method: Next-Generation Sequencing (NGS)

Component Tests Used: n/a

Reference Ranges Used:
Reference ranges for this test are not available online. However, they are included in all test results. For more information, please call us.

Specimen Type: peripheral blood (EDTA)
Volume: 5 mL (minimum: 2 mL)

Shipping: room temperature or 4C

Special Instructions: See requisitions for the full list of available testing and special instructions.

Testing Schedule(s): Please call

Turnaround Time: None

For more information, call 416.340.5227 or 1.866.865.5227