Laboratory Medicine Program

Hereditary Cancer - Ashkenazi Jewish Panel

Clinical Decription:
Individuals of Ashkenazi Jewish ancestry who do not meet other provincial criteria for hereditary cancer testing, may be eligible for targeted testing for a subgroup of inherited cancers. Please consult the Cancer Care Ontario document outlining eligibility for genetic testing for hereditary cancer (https://www.cancercareontario.ca/en/guidelines-advice/types-of-cancer/70161) and/or contact the lab for additional information. Note: This is a blood test for individuals with clinical and family histories suggestive of an inherited cancer syndrome. It is not a tumour test for somatic gene variants that provide information about diagnostics, prognostics or therapeutics.

Method: Next-Generation Sequencing (NGS)

Component Tests Used: n/a

Reference Ranges Used:
Reference ranges for this test are not available online. However, they are included in all test results. For more information, please call us.

Specimen Type: peripheral blood (EDTA)
Volume: 5 mL (minimum: 2 mL)

Shipping: room temperature or 4C

Special Instructions: Genes(APC[p.Ile1307Lys], BRCA1[c.185delAG/187delAG;c.5382insC/5385insC], BRCA2[c.617delT], CHEK2[c.1283C>T], GREM1[40kb dup], MSH2[p.Ala636Pro], MSH6[c.3984_3987dupGTCA;c.3959_3962delCAAG]) See requisitions for the full list of available testing and special instructions.

Testing Schedule(s): Please call

Turnaround Time: None

For more information, call 416.340.5227 or 1.866.865.5227