Laboratory Medicine Program

Hereditary Comprehensive Cancer Panel

Clinical Decription:
A proportion of individuals develop cancer because of an inherited cancer predisposition. Individuals who have personal and family histories of multiple cancers that may be suggestive of one of several hereditary cancer syndromes may be eligible for broad hereditary cancer genetic testing. Please contact the lab for additional information about whether this testing is appropriate. Note: This is a blood test for individuals with clinical and family histories suggestive of an inherited cancer syndrome. It is not a tumour test for somatic gene variants that provide information about diagnostics, prognostics or therapeutics.

Method: Next-Generation Sequencing (NGS)

Component Tests Used: n/a

Reference Ranges Used:
Reference ranges for this test are not available online. However, they are included in all test results. For more information, please call us.

Specimen Type: peripheral blood (EDTA)
Volume: 5 mL (minimum: 2 mL)

Shipping: room temperature or 4C

Special Instructions: Gene (AIP, APC, ATM, AXIN2, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDC73, CDH1, CDK4, CDKN1B, CDKN2A, CHEK2, CTNNA1, DICER1, EGLN1, EPCAM*, FH, FLCN, GALNT12, GREM1*, HOXB13, KIT, LZTR1, MAX, MEN1, MET, MITF, MLH1, MLH3, MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NF2, NTHL1, PALB2, PDGFRA, PMS2, POLD1, POLE, POT1, PTCH1, PTEN, RAD51C, RAD51D, RB1, RET, RNF43, RPS20, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, SMARCB1, SMARCE1, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL) See requisitions for the full list of available testing and special instructions.

Testing Schedule(s): Please call

Turnaround Time: None

For more information, call 416.340.5227 or 1.866.865.5227