Laboratory Medicine Program

Chronic Lymphocytic Leukemia: IGHV Somatic Hypermutation
(for patients requiring treatment)

Clinical Decription:
Chronic Lymphocytic Leukemia (CLL) is a mature B cell cancer usually found in the blood. The genetics of the immunoglobulinheavy chain (IGH) receptor in patients with CLL can be stratified into 2 groups. One with many mutations occuring called hypermutated and the other that contains very few mutations called unmutated when compared to a reference. Patients with hypermutated  IGH usually have better prognosis and respond to standard chemotherapies. Patients with unmutated IGH usually have worse outcomes, don't respond well to chemotherapy but will respond to BTK type inhibitors.

Method: Next-Generation Sequencing (NGS)

Component Tests Used: n/a

Reference Ranges Used:
Reference ranges for this test are not available online. However, they are included in all test results. For more information, please call us.

Specimen Type: peripheral blood (EDTA)
Volume: 5 mL (minimum: 2 mL)

Shipping: room temperature or 4C

Special Instructions: See requisitions for the full list of available testing and special instructions.

Testing Schedule(s): Please call

Turnaround Time: None

For more information, call 416.340.5227 or 1.866.865.5227