Laboratory Medicine Program

Creatinine clearance

Clinical Decription:
The creatinine clearance test is a relatively accurate and useful measure of the glomerular filtration rate. Creatinine occurring through metabolic production is eliminated from the plasma predominately by glomerular filtration, therefore a measurement of its rate of clearance affords a measure of this process. The creatinine clearance test is a calculation that utilizes the concentration of creatinine in the urine, concentration of creatinine in plsma, volume of the 24 hr urine and body surface area in square meters (requires height and weight of patient).
<br/><em>Tietz NW. Textbook of Clinical Chemistry 2nd ed. W.B. Saunders Co. Philadelphia, 1982:986-88</em>

Method: Automated method plus calculation; Advia

Component Tests Used: n/a

Reference Ranges Used:
Corrected to body surface area of 1.73 m2 (age/ sex / diet dependent) > 1.3 mL/s

Specimen Type: Green, lithium heparin, urine (24hr)
Collected In: Lithium heparin
Volume: 2.0- plasma, 20 - urine mL (minimum: 1.0 plasma, 10 - urine mL)

Shipping: 4C

Special Instructions: Discard first morning sample, collect all other urine for a 24 hour period, to include second morning sample. Record volume, heaight and weight of patient and aliquot sample. Obtain blood within the 24 hours of urine collection. Blood - Centrifuge Urine - Record volume and aliquot

Testing Schedule(s): Daily.

Turnaround Time: 3 days

For more information, call 416.340.5227 or 1.866.865.5227