Laboratory Medicine Program

Hemoglobin A1c
(Hb A1c, Glycated hemoglobin)

Clinical Decription:
HbA1c is formed by non-enzymatic post-translational glycosylation of HbA (at the N-terminal valine of the beta chain) during the 120 day life span of the erythrocytes. As the formation of HbA1c is irreversible, it accumulates in the red cells. It is present in increased amounts in patients with diabetes mellitus as a consequence of increased glucose levels. Thus, the level of HbA1c is used to assess the degree of control in the diabetic patients. Abnormal red cell survival: Samples from patients with hemolytic anemias exhibit decreased Hemoglobin A1c values due to the shortened life span of the red cells. This effect depends on the severity of the anemia. Similarly, samples from patients with polycythemia or post-splenectomy may exhibit HbA1c values due to a somewhat longer life span of the red cells.
<br/><em>Variant II Manufacturer's Manual</em>

Method: HPLC; Biorad D-100

Component Tests Used: n/a

Reference Ranges Used:
Screening: <5.5% Normal Glycemic control, 5.5-5.9% At risk:Rescreen more often, 6.0-6.4% Prediabetes, Diagnosis >=6.5%, Monitoring <=7.0% Recommended target for most adults with Type 1 or 2 diabetes

Specimen Type: Lavender EDTA
Collected In: EDTA
Volume: 3 mL (minimum: 1 mL)

Shipping: 4C

Special Instructions: n/a

Testing Schedule(s): Monday through Friday 0900-1500 hrs.

Turnaround Time: 5 days

For more information, call 416.340.5227 or 1.866.865.5227