Laboratory Medicine Program

Renin concentration

Clinical Decription:
Renin is a proteolytic acidic enzyme produced and secreted by the juxtaglomerular cells. It cleaves angiotensinogen into angiotensin I (inactive), which ultimately leads to the production of angiotension II (active). Renin which has a limitating effect on the production of angiotensin, is a key factor in the regulation of arterial pressure and hydrosodic metabolism. Renin is secreted by the kidneys in response to a reduction in the perfusion of the renal artery (intrarenal baroceptor), a reduction of distal tubular reabsorption of sodium (sodium leakage), an hypokaliemia or a B-adrenergic stimulation. Renin secretion is reduced (negative feed back) when there is a high plasmatic concentration of angiotensin II.
<br/><em>Renin Concentration Assay Kit</em>

Method: Chemiluminescent ; Liaison

Component Tests Used: n/a

Reference Ranges Used:
Normal salt diet (100-180 mmol/d);Recumbent (overnight or 6 h);0-11.2 ; ng/L|;Upright 2 h;6.1-22.9;ng/L|Low Na diet (10 mmol/d for 4 d);Recumbent (overhight or 6 h);6.8-27.1;ng/L|;Upright 2 h;10.2-50.0;ng/L|;Upright (2 h) + diuretic;13.7-93.4;ng/L Aldosterone: Renin ratio:

Specimen Type: Lavender EDTA
Collected In: EDTA
Volume: 2.5 mL (minimum: 2 mL)

Shipping: Frozen at -20C

Special Instructions: Centrifuge,aliquot and freeze sample at -20 degrees

Testing Schedule(s): once a week.

Turnaround Time: 7-10 days

For more information, call 416.340.5227 or 1.866.865.5227