Laboratory Medicine Program

Beta-2-microglobulin, serum
(B2-M)

Clinical Decription:
Beta-2-microglobulin is particularly rich on the surface membrane of B and T lymphocytes and all nucleated cells. Circulating beta-2-microglobulin is filtered by the glomeruli and 99.9% is reabsorbed and degraded in the proximal tubules and excreted in the urine. Reduced glomerular filtration rate causes an increase concentration of beta-2-microglobulin and creatinine in the serum. Beta-2-microglobulin is non-covalently bound to light chain of the human leukocyte antigen (A, B and C) class I so an increase level in the serum reflects immune disease progression in the body. Determination of beta-2-microglobulin is used to monitor lymphoproliferative diseases such as multiple myeloma, chronic lymphocytic lymphoma, non-Hodgkin’s lymphoma, Hodgkin’s disease, systematic lupus erythematosus, rheumatoid arthritis and kidney disorders.
<br/><em> HICL Reference Manual</em>

Method: Chemiluminescent immunoassay (CLIA); Liason

Component Tests Used: n/a

Reference Ranges Used:
0.6-2.30 mg/L

Specimen Type: serum
Volume: 3 mL mL (minimum: 1 mL mL)

Shipping: Frozen at -20C

Special Instructions: Centrifuge and aliquot sample.

Testing Schedule(s): 1 week.

Turnaround Time: 7-10 Business days

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