Laboratory Medicine Program

Thyroglobulin

Clinical Decription:
Thyroglobulin (TG) is a heterogeneous iodoglycoprotein which has a molecular mass of approximately 660,000 Dalton. Thyroglobulin is normally synthesized in the follicular cells of the thyroid gland, under the influence of thyrotropin and represents the precursor to the thyroxine and the other iodothyronines. Thyroglobulin levels tend to be elevated in regions of endemic goiter. The major clinical application for measurement of this prohormone derive form the fact that functioning thyroid tissue appears to be the only source circulating thyroglobulin. Accordingly thyroglobulin determinations have been widely used to complement radioiodine scanning and other techniques as an aid in identifying the presence or absence of functioning thyroid tissue. The differential diagnosis of congenital hypothyroidism is a well-established context of use for this application of serum thyroglobulin measurement.
<br/><em>Cobas e411 Manufactuere's Manual</em>

Method: Immunoassay; Cobas e411

Component Tests Used: n/a

Reference Ranges Used:
< 55 ug/L

Specimen Type: serum
Volume: 4 mL (minimum: 2 mL)

Shipping: 4C

Special Instructions: Centrifuge and aliquot sample.

Testing Schedule(s): Weekly.

Turnaround Time: 5 days

For more information, call 416.340.5227 or 1.866.865.5227