Laboratory Medicine Program

Glucose-6-phosphate dehydrogenase
(GPD, G6PD, G-6-PD)

Clinical Decription:
G6PD activity is used for identifying G6PD deficiency that can be asymptomatic or underlie acute hemolytic anemias and chronic hemolysis. G6PD deficiency is an X-linked disorder caused by mutations in the G6PD gene. This condition can be asymptomatic, although patients can present with chronic hemolysis or episodic anemia following exposure to infections, fava beans or drugs (Higgins V. JALM 2021). However, transfusion of red blood cell products less than 3 months prior to testing, significantly elevated reticulocytes and significantly elevated leukocyte counts, can falsely elevate G6PD levels. In neonates where there is a strong clinical suspicion of G6PD deficiency, retesting in 3 months and/or referral to a paediatric haematologist for further evaluation may be warranted.

Method: Kinetic Spectrophotometry; Alinity c

Component Tests Used: n/a

Reference Ranges Used:
7 - 18 U/g Hb

Specimen Type: ACD (yellow top), whole blood
Volume: 3 mL (minimum: 1 mL)

Shipping: 4C

Special Instructions: Whole blood required. Do not centrifuge. Do not freeze.

Testing Schedule(s): Weekly.

Turnaround Time: 7 days

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For more information, call 416.340.5227 or 1.866.865.5227

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