Laboratory Medicine Program

Lithium
(Carbolith)

Clinical Decription:
Lithium in the form of lithium carbonate is used in the treatment of the manic stage of manic-depressive psychosis. Evidence shows that lithium works by altering sodium transport and by interfering with ion exchange mechanisms and nerve conduction. Therapeutic use of lithium requires periodic monitoring of the serum lithium content, as toxicity can occur at concentrations above 1.5 mmol/L. Symptoms such as tremors, slurred speech, vomiting, diarrhea and drowsiness are seen as toxic reactions.

Method: Colorimetric; Architect c8000

Component Tests Used: n/a

Reference Ranges Used:
<65 years: 0.5-1.2 mmol/L: >= 65 Years 0.5-1.0 mmol/L : Critical >=1.5 mmol/L

Specimen Type: serum
Volume: 3 mL (minimum: 1 .0 mL)

Shipping: room temperature or 4C

Special Instructions: Optimum sampling time is trough level 12 h after the last dose or just prior to next dose

Testing Schedule(s): Daily.

Turnaround Time: 1 day

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