Laboratory Medicine Program

Anti-neutrophil cytoplasmic antibodies
(ANCA, p-ANCA, c-ANCA)

Clinical Decription:
Presence of antibodies directed against an elastinolytic serine protease similar to proteinase 3 (PR3) is highly specific for Wegener granulomatosis. Antibodies directed against myeloperoxidase (MPO) is identified to be associated with idiopathic glomerulonephritis.
<br/><em>Roberts DE, Rubin RL. Anti-Neutrophil cytoplasmic autoantibodies. In Rose NR, Conway de Macario E, Fahey JL, Friedman H, Penn GM, editors. Manual of Clinical Laboratory Immunology, 4th edition. Washington DC: American Society for Microbiology, 1992: 781-784.</em>

Method: Luminex; Bioplex

Component Tests Used: Anti-MPO, anti-PR3

Reference Ranges Used:
Less than 1.0 AI units

Specimen Type: Serum
Volume: 3 mL (minimum: 1 mL serum mL)

Shipping: 4C

Special Instructions: n/a

Testing Schedule(s): Monday to Friday.

Turnaround Time: 3 days

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For more information, call 416.340.5227 or 1.866.865.5227

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