Laboratory Medicine Program

Phospho-Tau 217, Plasma
(pTau217)

Clinical Decription:
Plasma Phospho-Tau 217 (pTau217) is a biomarker of Alzheimer disease–associated pathology that correlates strongly with cerebral amyloid-ß deposition. Testing is intended to support the diagnostic evaluation of individuals aged 50 years and older who present with cognitive impairment and are being assessed for Alzheimer disease or other causes of cognitive decline. This test is not intended as a screening test for Alzheimer disease in asymptomatic individuals.

Method: ECLIA; Roche Cobas e402

Component Tests Used: n/a

Reference Ranges Used:
Negative: </= 0.223 ng/mL | Intermediate: 0.224-0.378 pg/mL | Positive: >0.378 pg/mL

Specimen Type: Plasma
Volume: 1.0 mL (minimum: 1.0 mL)

Shipping: Ship frozen at -20°C

Special Instructions: Submit EDTA plasma only; no alternative specimens are accepted. Aliquot and freeze at -20°C, then ship frozen on dry ice. Specimen stability is 2 days at 20–25 °C, 7 days at 2–8 °C, or 3 months at -20 °C. Freeze only once; do not refreeze after thawing.

Testing Schedule(s): Batch testing; every 2-3 weeks.

Turnaround Time: 15 days

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For more information, call 416.340.5227 or 1.866.865.5227

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